Biologic differences between peripheral and transition zone prostate cancer
نویسندگان
چکیده
منابع مشابه
Biologic differences between peripheral and transition zone prostate cancer.
BACKGROUND Prostate cancer arises in the transition zone (TZ) in approximately 20-25% of cases. Modern biopsy and surveillance protocols, and advances in prostate cancer imaging, have renewed interest in TZ prostate cancers. We compared TZ and PZ prostate cancer to determine if cancer location is independently associated with better outcomes. METHODS We evaluated an expanded cohort of 1354 me...
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Prostate tumors arise primarily in the peripheral zone (PZ) of the prostate, but 20-30% arise in the transition zone (TZ). Zone of origin may have prognostic value or reflect distinct molecular subtypes; however, it can be difficult to determine in practice. Using whole-genome gene expression, we built a signature of zone using normal tissue from five individuals and found that it successfully ...
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ژورنال
عنوان ژورنال: The Prostate
سال: 2014
ISSN: 0270-4137
DOI: 10.1002/pros.22903